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Furadantin: Oral suspension (25mg)

The localization and nature of the elements of the rash in Abt-Letterer-Siwe disease are very similar to the manifestations of seborrheic dermatitis, the diagnosis of which is usually made at the beginning. However, a closer examination reveals petechial elements, dotted scars at the site of former lichenoid papules, which is not observed in seborrheic dermatitis. The general condition of the child, the nature of the damage to other organs and systems (polyadenopathy, destructive changes in bone tissue, lung damage, otitis media and mastoiditis, hepatosplenomegaly, laboratory data) also speak against seborrheic dermatitis. In case of difficulties in diagnosis, the data of histological examination of the elements of the rash and lymph nodes help.

In cytological studies made using a puncture biopsy, 4 types of cells were found in smears among erythrocytes, leukocyte and reticulohistiocytic elements. furadantin pills refers to the first type as small cells, often of irregular shape, with mesh or homogeneous protoplasm and usually loose nuclei. The second type is multinucleated (from 4 to 7 nuclei) cells, the nuclei are predominantly round and loose. The third type includes cells containing large, medium and small vacuoles.

Cells of the fourth type are represented by macrophages, among which there are multinucleated giants. The nature of the cellular infiltrate depends on the form of histiocytosis and on the duration of the existence of the lesion. In fresh foci, type 1 cells and eosinophils prevail, with the progression of nitrofurantoin online, type 3 cells appear, and later type 4 cells are observed and the number of eosinophils is reduced.

The dose of the drug (in terms of prednisolone) should be from 1 to 2 mg per 1 kg of body weight per day. A gradual decrease in the dose of the drug continues for several months, and sometimes years, until a more or less prolonged remission. In cases of accession of intercurrent diseases (OVRI, chickenpox, measles, scarlet fever, etc.), as a rule, an exacerbation of the disease occurs, which dictates the need to increase the dose of glucocorticoid for this period and prescribe antibiotics for 3-4 weeks. Courses of antibiotics are periodically repeated. In combination with glucocorticoids, a number of patients are prescribed cytostatic agents (6-mercaptopurine, leukeran, degranol, etc.) for health reasons.